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The Dyspnea Lab at Harvard

SHORTOFBREATH.ORG The Dyspnea Lab at HarvardSHORTOFBREATH.ORG The Dyspnea Lab at HarvardSHORTOFBREATH.ORG The Dyspnea Lab at Harvard

SHORTOFBREATH.ORG
The Dyspnea Lab at Harvard

SHORTOFBREATH.ORG The Dyspnea Lab at HarvardSHORTOFBREATH.ORG The Dyspnea Lab at HarvardSHORTOFBREATH.ORG The Dyspnea Lab at Harvard
  • Home
  • Neurophysiology
  • Dyspnea in the Brain
  • Model and Measurement
  • Clinical Translation
  • Banzett Publications
  • News Articles and Youtube
PET scan of Air Hunger showing activation of anterior insula

From basic physiology to clinical research

Brief Introduction

The Dyspnea Lab at Harvard (Headed by Bob Banzett and Bob Lansing)  worked for more than 3 decades to discover the basic neural mechanisms  underlying the symptom of dyspnea (shortness of breath, breathlessness).  We utilized methods from respiratory physiology, experimental  psychology, and neuroscience. Using pharmacological interventions,  clinical lesions, and functional brain imaging we defined neural  pathways and brain regions subserving dyspnea.  We went on to improve measurement of dyspnea, and to apply what we had learned to clinical investigation.  

(Disclaimer - this website emphasizes the significant contributions of the Dyspnea Lab, but we could not have done so much without the terrific work of the many scientists who went before us and beside us.  They are generally not cited on this website, but they are cited in our published papers.)

Lab closed, education goes on

March 2024: Although the lab is closed now, we are rebuilding this  website to include summaries of our work, links to our papers, and  educational videos. This site will continue to grow throughout the year.  Please check back later.  Our comprehensive review of Air Hunger is now available in free PMC form.  CLICK HERE

Upcoming event

Join us for Dyspnea 2026 in Lund, Sweden!   This is a 2 1/2 – day international scientific meeting for  physiologists, psychologists, neuroscientists, and clinicians with an  interest in dyspnea research.  Visit https://dyspneasociety.org/index.html for more info.

What is that image at the top of the page?

 The  image shown in the header is the first functional brain image of  dyspnea. Dyspnea is a perceived sensation, thus it must be sited somewhere in the cerebral cortex.  Prior to this image we had no idea where in the cortex dyspnea  is perceived.  The main activation found was in the right anterior insula, a location also important to perception of pain, thirst, and hunger. 

(Banzett, Adams et al Neuroreport 2000)

Our research accomplishments

neural pathways for air hunger

Neural Pathways

Dyspnea in the Cerebral Cortex

Dyspnea in the Cerebral Cortex

We developed laboratory models of dyspnea sensations.  Using these models together with clinical and pharmacological neural lesions we identified peripheral and central neural pathways involved in dyspnea perception 

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Dyspnea in the Cerebral Cortex

Dyspnea in the Cerebral Cortex

Dyspnea in the Cerebral Cortex

Because dyspnea is consciously perceived, we knew it must be represented in the cerebral cortex, but, in contrast to other sensations such as touch, hearing, sight, pain, nobody knew what region of the cortex perceives dyspnea. We used functional brain imaging to discover the cortical sites involved in dyspnea perception.

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Theory and Measurement

Dyspnea in the Cerebral Cortex

Theory and Measurement

We developed a  theoretical framework in which dyspnea comprises several sensations.  having a sensory quality and an affective component.  Based on this, we developed a unified measurement instrument , the  Multidimensional Dyspnea Profile (MDP).

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Clinical translation

Dyspnea in the Cerebral Cortex

Theory and Measurement

We worked with nurses throughout our hospital to measure dyspnea in all patients. In addition to its value in symptom management, we found that patient-reported dyspnea strongly predicts adverse outcomes. We also used our laboratory models to examine effectiveness of interventions to relieve dyspnea.

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  • Home
  • Neurophysiology
  • Dyspnea in the Brain
  • Model and Measurement
  • Clinical Translation
  • Banzett Publications

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